ABSTRACT
The present work carries an analytical method development of prednisolone and 5- amino salicylic acid in tablet dosage form. The method is based upon Q – absorption ratio method for the simultaneous determination of the prednisolone and 5-amino salicylic acid. Both the drugs are widely used for bacterial cure and are recommended for the patients with mild to moderate inflammation of the digestive tract. Ulcerative colitis and crohn’s disease are the target disorders which are treated by both drug candidates. Absorption ratio method is used for the ratio of the absorption at two selected wavelength one of which is the iso-absorptive point and other being the λmax of one of the two components. Prednisolone and 5-ASA shows their iso-absorptive point at 283 nm in ethanol and 0.1N HCl respectively. The second wavelength used is 302 nm which is the λmax of 5-ASA in 0.1N HCl. The linearity was obtained in the concentration range of 1-10 μg/ml for prednisolone and 5-ASA. This method was applied to all pharmaceutical dosage form because there is no excipients interference between them. The results have been validated by recovery studies.
ABSTRACT
Dietary habits have been associated with variations in the risk of colon disorders, either its increase or decrease. Colon-specific approaches showed their potential to target and treat colon cancers and inflammatory diseases, but they vary in success rates for local recurrence, disease-free survival, and overall survival. Also, chemotherapies and radiotherapies have been applied as the surgical adjuvant treatments. The significant role of exogenously administered Lactobacilli in reducing toxin-producing bacteria in the gut and increases the longevity of the host, led to the coining of the term ‘probiotics’. The evidence on the effects of inulin and oligofructose on colonization, translocation of pathogens and the prevention of intestinal diseases make them suitable candidates to treat colon disorders. Among potentially protective foods, growing attention has been dedicated to functional foods comprising probiotics, such as Lactobacilli or Bifidobacteria, and prebiotics such as fructooligosaccharides or fructans, as their consumption may treat inflammatory bowel diseases, like ulcerative colitis, crohn’s disease as well as experimentally induced colon cancer in mammals. The readily apparent synergy of concomitantly using beneficial microorganisms and nutritive materials that support their growth led to the term “synbiotics” to describe foods or supplements that combine both probiotics and prebiotics. Various potential mechanisms are addressed in the present paper. This article discusses the real value of dietary components, which offers practical information to help patients as well as health professionals. Furthermore, article has focused on the possible value of probiotics, prebiotics and synbiotics in treatment and maintenance therapy of colonic ailments.
ABSTRACT
Various minerals have been reported which are directly linked to our health and cancer development in body. The immune system (immunoglobulin’s, cell mediated immunity, phagocytosis complement, lysosomes, interferon, metabolic function, hormones, metabolic and respiratory alkalosis) is the natural mechanism which defends against cancer. Minerals like zinc, selenium, magnesium, vanadium, and germanium augment this natural mechanism. In this review various aspects of these mineral are discussed and their relation with cancer.
ABSTRACT
Colon specific drug delivery has achieved utmost importance because the colon is an area that is vulnerable to a number of diseases including ulcerative colitis, crohn’s disease, irritable bowel syndrome and carcinomas. And, preservation of formulation in upper GIT to colon is still important step. Treatment of these diseases with a colon-specific drug delivery system provides an interesting alternative over systemic drug administration because of lower dosing and fewer systemic side effects. Different challenges are associated with this delivery system like long transit time, enzymatic interference, intersubject variation of microflora etc. A variety of under clinical and commercially available approaches were designed for remediation of colonic ailments. Different dosage forms like tablets, capsules, pellets, multiparticulates, microspheres, liposome, nanoparticulates etc. were used for colon targeting. The present review article mainly focused on different approaches, mainly on formulation, carrier system and/or coating system, bioactive stability, patient compliance and evaluation of colon specific drug delivery system.